Types of Studies
Maximization Patch Test
This test is designed to determine whether a test product will cause an allergy when applied to the skin. A small area (5/8 inch) of skin (upper back or arm) is exposed to each test product. To maximize the proper exposure of the skin to the test material, the skin site is first exposed to a dilute soap solution under a covered patch for 24 hours; a day prior to the application of the test product. The test material is then applied to the same site under a patch for 48 hours. The patch is then removed and the skin is examined. This sequence of dilute soap application followed by test product is repeated twice a week for a total of 3 weeks. After that, there is a 10 day rest period during which you do not have to come to the KGL Skin Study Center. Following the rest period, a dilute soap patch is applied for 30 minutes followed by the test product. The sites are checked 48 and 72 hours later to determine if allergy has developed (end of test).
Photomaximization Patch Test
This test is designed to determine whether a test product will cause an allergy when applied to the skin which is then exposed to light.The test product is applied to a small skin site (7/8 inch) over the lower back under a patch for 24 hours and exposed to light which simulates (mimics) natural sunlight (equivalent to about one hour of noontime sunlight). This sequence is repeated twice for three consecutive weeks. After that, there is a two week rest period during which you do not have to come to KGL Skin Study Center. At the end of the 2 week rest period, the product will again be applied to a skin site for the last time under a patch and then exposed to simulated sunlight 24 hours later. The site is examined 48 and 72 hours later to determine if allergy has developed (end of test).
Effectiveness studies vary in length from one week to several months. Most studies involve the daily application of products to the face. Application is typically done at home (unsupervised) or may be done under supervised conditions at KGL Skin Study Center. Periodic assessments are done (every 2 to 4 weeks) at KGL Skin Study Center and involve clinical assessments by expert graders and/or board certified dermatologists along with photography and instrumental measurements of the skin.